Croatoan

Wiki:

The Roanoke Colony on Roanoke Island in Dare County in present-day North Carolina was an enterprise financed and organized by Sir Walter Raleigh in the late 16th century to establish a permanent English settlement in the Virginia Colony. Between 1585 and 1587, several groups attempted to establish a colony, but either abandoned the settlement or disappeared. The final group of colonists disappeared after three years elapsed without supplies from England during the time when England was at war with Spain, leading to the continuing mystery known as "The Lost Colony". The most likely explanation is that they were assimilated into one of the local indigenous tribes.